well, after reading comments here I'm installing flux. I also do a lot of keyboard navigation. One of the browers I use, luakit, has an option where if you press the "f" key, it numbers all the links on the screen, in such a way that the links are spread out across numbers so you have a good chance of only having to type two numbers even on a page with lots of links. I use the Readability add on for FireFox if a page is too busy. I use ctrl + to make things bigger sometimes. I also use adblock but sometimes have to resort to zoom in + side scrolling to make animation go away.

I have a larger default text size set in my browser settings, which sometimes causes layouts of sites to break.